Neurontin for Bipolar (Gabapentin)
by Sarah from Bipolar-Lives
(FL, US)
US BRAND NAME: Neurontin
GENERIC NAME: Gabapentin
TYPE: Anticonvulsant
USE: Main use is to prevent epileptic seizures. It increases the amount of GABA in the brain (that is, the chemical gamma-aminobutyric acid), and works on the theory that epileptic seizures occur when there are low levels of GABA in the brain. Initially it was used off-label to treat bipolar disorder and other mental health conditions as it seemed to act as an antidepressant and an antianxiety medication at the same time. However, it is now acknowledged there is no evidence that it is effective as a mood stabilizer or anything else, and may make mental health deteriorate.
COMMENTS: Some people respond well as first but the effects do not seem to last.
EVIDENCE: There are no clinical studies showing it to perform better than a placebo (for treating bipolar disorder), and in one study it performed worse!
SIDE EFFECTS: Include but not limited to: Dizziness, drowsiness, weight gain, and peripheral edema (swelling of extremities) in adults. In children side efffects include mild-to-moderate mood swings, hostility, concentration problems, and hyperactivity.
CAUTIONS: Gabapentin should not be discontinued abruptly after long term use. Abrupt or over rapid withdrawal may provoke a withdrawal syndrome similar to alcohol or benzodiazepine withdrawal.